Table 3.
Associations of current and past cancer diagnosis with mortality and ICU admission in CEC-UW hospitalized patients in three different age groups.a
| Outcome | Unadjusted | Adjustedb | |||||
|---|---|---|---|---|---|---|---|
| Age, Cancer History | Mortality, N (%) | OR | 95% CI | P | OR | 95% CI | P |
| 18–59 Years | |||||||
| No Current or Past (Ref) | 1,495 (3.7) | 1.00 | — | — | 1.00 | — | — |
| Current | 180 (9.4) | 2.94 | 2.49–3.37 | < 0.001 | 2.62 | 2.20–3.12 | < 0.001 |
| Past (No Current) | 66 (5.1) | 1.45 | 1.12–1.87 | 0.005 | 1.05 | 0.80–1.36 | 0.182 |
| 60–70 Years | |||||||
| No Current or Past (Ref) | 2,092 (10.1) | 1.00 | — | — | 1.00 | — | — |
| Current | 305 (14.9) | 1.69 | 1.48–1.93 | <0.001 | 1.82 | 1.59–2.09 | <0.001 |
| Past (No Current) | 207 (11.7) | 1.23 | 1.05–1.43 | 0.010 | 1.20 | 1.02–1.40 | 0.026 |
| 71–90+ Years | |||||||
| No Current or Past (Ref) | 4,797 (16.0) | 1.00 | — | — | 1.00 | — | — |
| Current | 555 (17.4) | 1.27 | 1.15–1.40 | <0.001 | 1.26 | 1.14–1.40 | <0.001 |
| Pasta (No Current) | 556 (15.1) | 0.98 | 0.89–1.08 | 0.68 | 0.95 | 0.86–1.05 | 0.313 |
| Outcome | Unadjusted | Adjustedb | |||||
|---|---|---|---|---|---|---|---|
| Age, Cancer History | ICU, N (%) | OR | 95% CI | P | OR | 95% CI | P |
| 18–59 Years | |||||||
| No Current or Past (Ref) | 7,260 (18.1) | 1.00 | — | — | 1.00 | — | — |
| Current | 484 (25.4) | 1.49 | 1.34–1.67 | <0.001 | 1.37 | 1.22–1.53 | <0.001 |
| Past (No Current) | 274 (21.1) | 1.12 | 0.98–1.29 | 0.095 | 0.98 | 0.85–1.13 | 0.746 |
| 60–70 Years | |||||||
| No Current or Past (Ref.) | 4,919 (23.8) | 1.00 | — | — | 1.00 | — | — |
| Current | 551 (27.0) | 1.17 | 1.05–1.30 | 0 0.004 | 1.20 | 1.08–1.34 | 0.001 |
| Past (No Current) | 423 (23.9) | 0.93 | 0.82–1.04 | 0.191 | 0.93 | 0.82–1.04 | 0.200 |
| 71–90+ Years | |||||||
| No Current or Past (Ref.) | 5,884 (19.6) | 1.00 | — | — | 1.00 | — | — |
| Current | 728 (22.8) | 1.19 | 1.09–1.31 | <0.001 | 1.16 | 1.06–1.27 | 0.002 |
| Past (No Current) | 785 (21.3) | 1.00 | 0.92–1.09 | 0.933 | 1.00 | 0.91–1.09 | 0.936 |
Note: Tests of interactions for mortality, unadjusted F (4, 104,581) = 20,784, P < 0.001; adjusted F (4, 103,523) = 15,589, P < 0.001.
for ICU admission, unadjusted F (4, 104,580) = 5,028, P < 0.001; adjusted F (4, 103,522) = 5,282, P < 0.001.
Abbreviations: CEC-UW, COVID EHR Cohort at the University of Wisconsin; OR, odds ratio; ICU, admission to intensive care unit.
aSee Text S4 for the rationale for the use of these three age groups in lieu of the seven shown in Table 1.
bAdjusted for sex, continuous age, race, ethnicity, BMI, smoking status, insurance status, and past 5-year comorbidity score; covariate categorizations are given in Table 1.