Table 2.

CpGs associated with longitudinal HbA1c at FDR of <20% in the EDC study

ID	Chr	Location	CpG position	Gene symbol	Location relative to gene	β per 5% methylation	SE	P value	bacon-adjusted FDR*
cg19693031	1	Open Sea	145 441 552	TXNIP	3′UTR	−0.202	0.0273	9.23E-13	<0.0001
cg12578588	19	Open Sea	18 132 275	n/a	Intergenic	−0.436	0.0807	1.16E-07	0.0230
cg02988288	1	Open Sea	145 440 445	TXNIP	Body	−0.437	0.0831	2.31E-07	0.0326
cg21566642	2	Island	233 284 661	n/a	Intergenic	−0.157	0.0313	7.22E-07	0.1233
cg14885762	17	N.Shore	75 446 450	SEPT9	TSS200	−0.426	0.0867	1.32E-06	0.1015
cg20772590	17	N.Shore	75 446 431	SEPT9	TSS200	−0.491	0.1002	1.41E-06	0.1015
cg05575921	5	N.Shore	373 378	AHRR	Body	−0.110	0.0226	1.48E-06	0.1015
cg01940273	2	Island	233 284 934	n/a	Intergenic	−0.228	0.0474	2.12E-06	0.1292
cg26974062	1	Open Sea	145 440 734	TXNIP	Body	−0.437	0.0934	3.88E-06	0.1793
cg18984002	17	Open Sea	36 876 514	MLLT6	Body	−0.700	0.1502	4.23E-06	0.1793
cg25648203	5	Open Sea	395 444	AHRR	Body	−0.254	0.0544	4.26E-06	0.1793
cg04507446	16	N.Shore	422 157	TMEM8A	Body	−0.312	0.0669	4.48E-06	0.1793

Results of linear mixed models adjusted for type 1 diabetes duration, sex, pack years of smoking, estimated cell type composition variables, and plate/run indicator, well position, GCT bisulfite score, DNA extraction method, study visit of DNA collection, first two principal components of ancestry from genotyping arrays, and two surrogate variables from sva, sorted by p value in ascending order.

*Bolded row is significant at the Bonferroni-adjusted threshold p<7.3×10⁻⁸.

CpG, 5′-cytosine-phosphate-guanine-3′; EDC, Epidemiology of Diabetes Complications; FDR, false discovery rate; n/a, not applicable; TXNIP, Thioredoxin-Interacting Protein.