Knockdown of EFNA3 attenuates lung tissue damage in asthmatic mice. (A) H&E staining was performed to assess the degree of inflammatory cell infiltration in mice treated with OVA or/and EFNA3 knockdown. Scale bar 100 μm. (B) PAS staining was performed to detect changes in pathologic morphology in mice treated with OVA or/and EFNA3 knockdown. Scale bar 100 μm. (C) Masson’s staining was conducted to determine changes in mice treated with OVA or/and EFNA3 knockdown. Scale bar 100 μm. (D-G) Pathologic features including WAi/WAm (D), N/Pi (E), WAi/Pi (F), and WAm/Pi (G) of the lung tissues of mice treated with OVA and/or EFNA3 knockdown. *P < 0.05, **P < 0.01, ***P < 0.001 of one-way ANOVA with Tukey test.