KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Kim1	Novus	Cat# AF-1817
NGAL	Novus	Cat# AF-1857
CD68	Novus	Cat# 125212
CD3	abcam	Cat# MCA1477
Glutaminase	Bio-Rad	Cat# 56750
Glutamate dehydrogenase	Cell signaling	Cat# 12793
Kir4.2	Cell signaling	Cat# APC-058
LTL-fluorescein	Alomone	Cat# FL-1321-2
β-actin	Vector	Cat# A1978
GAPDH	Millipore	Cat# HRP-60004
S6 kinase (total)	Proteintech	Cat# 9202
phospho S6 kinase (T389)	Cell signaling	Cat# 9205
AKT (total)	Cell signaling	Cat# 4691
phospho AKT (S473)	Cell signaling	Cat# 4060
CD45-BV785	Cell signaling	Cat# 103149
CD11b-PerCP5.5	Biolegends	Cat# 45-0112-82
Ly6G-APC	Biolegends	Cat# 127614
F4/80-PE-Cy7	Biolegends	Cat# 123114
CD3-FITC	Biolegends	Cat# 100204
CD8-APC-Cy7	Biolegends	Cat# 100714
Chemicals, peptides, and recombinant proteins
pHrodo green	ThermoFisher	Cat# P35373
H2DCFDA	ThermoFisher	Cat# D399
BPTES	Selleck	Cat# S7753
Amiloride	Millipore Sigma	Cat# 1019701
Aldosterone	Millipore Sigma	Cat# A9477
DNAse I	BioRad	Cat #7326828
Collagenase D	Roche	Cat# 11088858001
Picrosirius red	MilliporeSigma	Cat# 365548
Critical commercial assays
Superscript IV First Strand Synthesis System Kit	ThermoFisher	Cat# 18091050
Aldosterone ELISA	IBL America	Cat# IB79134
Ammonium assay	Pointe Scientific	Cat# 23-666-102
Creatinine companion	EXOCELL	Cat# 1012
BCA Protein Assay	ThermoFisher	Cat# 23225
Experimental models: Cell lines
Renal proximal tubule epithelial cells	ATCC	PCS-400-010
Experimental models: Organisms/strains
Kir4.2 knockout animals	Vanderbilt University	N/A
Glutaminase floxed animals	Jackson Labs	017956
Pax8-LC1 transgenic animals	Dr. Leslie Gewin	N/A
Oligonucleotides
See Tables S8 and S9		N/A
Software and algorithms
Graphpad Prism v9	Graphpad Software, LLC	https://www.graphpad.com/scientific-software/prism/
QuPath	Relman and Schwartz18	https://qupath.github.io/