Fig. 2.

Analysis of miRs associated with mitochondrial health and function. (A) Significant dysregulation of circulating miRs related to the expression and assembly of mitochondrial respiratory chain in patients with Fabry disease (FD). Median (dashed line) and quartiles (dotted lines) are indicated in the violin plots. (B) Western blot analysis of mitochondrial ETC in PBMCs revealed a significant downregulation of I-II-IV and ATP synthase complexes in FD; actin was used as loading control; data are mean ± S.E. (C) Purified proteins provided by the supplier, used as molecular weight referrals. *P < 0.05, **P < 0.005, ***P < 0.0005, FD versus control. CTRL +, positive control.