Table 1.
Characteristics of individuals with regards to clinical outcomes.
| MRS ≤ 2 | MRS > 2 | P Value | |
|---|---|---|---|
| N | 20 | 31 | |
| Age (median; IQR) | 66 (55, 79) | 72 (62, 83) | P = .120 |
| Gender (Male) | 9 (45%) | 18 (58.1%) | P = .366 |
| NIHSS admission (median; IQR) | 6 (6, 12) | 13 (6, 27) | P < .001 |
| NIHSS discharge (median; IQR) | 2 (1,4) | 13 (4, 28) | P < .001 |
| NIHSS 3 months (median; IQR) | 1 (0, 2) | 9 (4,28) | P < .001 |
| MRS at discharge (median; IQR) | 2 (1, 2) | 4 (3,5) | P < .001 |
| Cardiovascular risk factors | |||
| Diabetes mellitus (%) | 4 (20%) | 12 (38.7%) | P = .164 |
| Hypertension (%) | 13 (65%) | 28 (90.3%) | P = .028 |
| Dyslipidemia (%) | 11 (55%) | 23 (74.2%) | P = .160 |
| Atrial fibrillation (%) | 8 (40%) | 15 (48.4%) | P = .561 |
| Smoking (%) | 6 (30%) | 6 (19.4%) | P = .386 |
| Chronic kidney disease (%) | 0 | 2 (6.5%) | P = .251 |
| Illicit drug use (%) | 1 (5%) | 1 (3.2) | P = .752 |
| Ischemic heart disease (%) | 3 (15%) | 5 (16.1%) | P = .915 |
| Intervention | |||
| Recombinant tissue plasminogen activator (%) | 7 (35%) | 6 (19.4%) | P = .215 |
| Mechanical thrombectomy (%) | 5 (25%) | 7 (22.6%) | P = .844 |
| Stroke subtype | |||
| Large arterial occlusion (%) | 5 (26.3%) | 10 (32.3%) | P = .582 |
| Cardioembolic (%) | 7 (35%) | 16 (51.6%) | P = .249 |
| Small vessel disease (%) | 8 (40%) | 2 (6.5%) | P = .04 |
| Other determined (%) | 0 | 1 (3.2%) | P = .422 |
| ESUS (%) | 0 | 1 (3.2%) | P = .422 |
| Hemorrhagic transformation | |||
| All subtypes (%) | 4 (20%) | 8 (31.5%) | P = .637 |
| Symptomatic HT | 1 (5%) | 7 (22.6%) | P = .07 |
| Hemorrhagic infarction 1 (%) | 1 (5%) | 1 (3.2%) | P = .752 |
| Hemorrhagic infarction 2 (%) | 1 (5%) | 1 (3.2%) | P = .752 |
| Petechial hemorrhage 1 (%) | 1 (5%) | 4 (12.9%) | P = .359 |
| Petechial hemorrhage 2 (%) | 1 (5%) | 2 (6.5%) | P = .831 |
| NFL value pg/Ml | |||
| NFL first sample pg/mL (median; IQR) | 21.39 (9.28, 44.42) | 26.69 (15.10, 64.39) | P = .177 |
| NFL second sample pg/mL (median; IQR) | 49.06 (25.22, 65.16) | 71.41 (47.58, 153.50) | P = .011 |
| Incremental rate NFL pg/dL × day (median; IQR) | 7.12 (1.09,11.93) | 24.07 (6.27, 40.30) | P = .004 |
Abbreviation: IQR, interquartile range; NFL, plasma neurofilament light, NIHSS, National Institutes of Health Stroke Scale; mRS, modified rankin score; ESUS, embolic stroke of undetermined source.