Figure EV2. No difference in the colitis model or activation of the MAPK and NF‐κB pathways was observed between WT and XAF1^MKO mice.

• A, B
  Body weight loss (A) and stool diarrhea and hematochezia scores (B) in WT and XAF1^MKO mice of the DSS‐induced colitis model.
• C, D
  Colon length (C) and proinflammatory cytokine production (D) of DSS‐treated WT and XAF1^MKO mice on day 8.
• E, F
  The indicated proteins in cytoplasmic (CE) and nuclear extracts (NE) of WT and XAF1‐deficient BMDMs were detected by IB.
• G
  The activation of MAPKs in total cell lysates was measured by IB.

Data information: The data are representative of at least three biologically independent experiments. Data from the qPCR assay are presented as the fold change relative to the Actin mRNA level. Data are represented as the means ± SDs. The significance of differences was determined by a t‐test.

Source data are available online for this figure.