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. 2022 Dec 19;24(1):e56033. doi: 10.15252/embr.202256033

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© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Clock‐wise from the top: natural product‐derived antibiotics (79%): cephalosporins (24), penicillins (14), aminoglycosides (8), tetracyclins (5), glycopeptides (4), rifamycins (3), macrolides (3), carbapenems (3), polypeptides (2), amphenicol (1), daptomycin (1), fosfomycin (1)*, lincosamid (1), monobactams (1), nitroheterocycles** (1), pleuromutilins (1), streptogramins (1); antibiotics with synthetic origin (21%): sulfonamides (9), fluoroquinolones (7), oxazolidinones (2), aminopyrimidine (1), nitroheterocycles** (1). *not yet approved in the United States (Werth, 2022), **The nitroheterocyle metronidazole is derived from a natural product whereas nitroheterocycle nitrofurantoin is of synthetic origin. Source data are in Appendix Table S1.Source data are available online for this figure.