Figure 2.

Histologic lesions noted coronavirus infected in α1 anti-trypsin deficient ferrets. (A–B) Ferret 749 displayed grossly enlarged (A) spleen and (B) mesenteric lymph nodes with firm, irregular red to tan nodules extending from the capsular surfaces (arrows). (C–F) Histologic evidence of (C) pyogranulomas containing a central core of non-viable neutrophils surrounded by epithelioid macrophage as seen in this H+E image of spleen (40× magnification) or (D) foci of viable and necrotic macrophage containing amphophilic, vacuolated cytoplasm as seen in this H+E image of mesenteric lymph node (40× magnification). Similar inflammatory lesions were noted in the (E) pancreas, effacing normal acinar cell lobules with small numbers of residual acinar cells (arrows) or (F) extending into the small intestine through the serosa.