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. 2023 Jan 9;22:3. doi: 10.1186/s12943-022-01711-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Design and killing assay of GD2 specific 4SCAR-T cells. A Design of GD2 specific 4SCAR-T cells. B Study design of killing assay of peripheral blood mononuclear cells (PBMCs), CD19 specific 4SCAR-T cells and GD2 specific 4SCAR-T cells against primary GBM cells. The primary GBM cells transduced with a lentiviral wasabi green fluorescence reporter gene were used as target cells, and plated into 48-well plate before co-culturing with different cells (E:T ratio 4:1). C Fluorescence microscopy of primary GBM cells from Patient 01 on 24, 48 and 72 h after co-culture. D-K The percentage of lysed primary GBM cells from indicated patients. All data are represented as the mean ± SEM. *p < 0.05, GD2 4SCAR-T vs. PBMC; #p < 0.05, GD2 4SCAR-T vs. CD19 4SCAR-T (One-Way ANOVA)