Table 1.
Patient No. | Age (y) /Sex |
Diagnosis | Prior Treatment | CAR-T Cells Dose and Routes | ||||
---|---|---|---|---|---|---|---|---|
Surgery |
Radiation
+ TMZ |
IDH1/2 | MGMT | GD2 Intensity | ||||
01 | 63/F | GBM | Yes,×2 | TMZ, No Radiation | WT | UM | 4.0+ |
i.v. 1.3 × 108 i.c. 5 × 106 |
02 | 4/M | GBM | Yes,×2 | Radiation, No TMZ | WT | UM | 3.0+ |
i.v. 6.4 × 107 i.c. 2.6 × 106 |
03 | 6/F | GBM | Yes | Yes | WT | UM | 2.0+ | i.v. 4.6 × 107 |
04 | 38/F | GBM | Yes | Yes | WT | UM | 2.5+ | i.v. 1.4 × 108 |
05 | 29/M | GBM | Yes,×2 | Yes | WT | ML | 2.0+ |
i.v. 1.6 × 108 i.c. 6.4 × 106 |
06 | 3/M | GBM | Yes | Radiation, No TMZ | WT | UM | 3.5+ | i.v. 3.8 × 107 |
07 | 5/F | GBM | Yes | Radiation, No TMZ | WT | UM | 1.5+ | i.v. 3 × 107 |
08 | 31/M | GBM | Yes | Yes | WT | UM | 3.5+ | i.v. 2.1 × 108 |
TMZ Temozolomide, WT Wildtype, UM Unmethylated, ML Methylated, i.v. Intravenous, i.c. Intracavitary