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. 2023 Jan 9;22:3. doi: 10.1186/s12943-022-01711-9

Table 2.

Adverse events within the first 4 weeks after GD2-specific 4SCAR-T cell infusion

Adverse
Event
No. of Patients (n = 8) Adverse
Event
No. of Patients (n = 8)
Garde 2 Grade 3 Grade 4 Garde 2 Grade 3 Grade 4
Probably related Respiratory
Central nervous system 0 0 0 Atelectasis 0 0 0
Headache 0 1 0 Pain
Seizure 1 0 0 Extremity 0 0 0
Unrelated Bone 0 0 0
Hematologic toxic Myalgia 4 1 0
Anemia 2 0 0 Musculoskeletal
Lymphopenia 4 1 0 Edema, localized 0 0 0
Neutropenia 5 0 0 Fracture 0 0 0
Thrombocytopenia 0 0 0 Central nervous system
Nonhematologic toxic Headache 1 1 0
General Seizure 0 0 0
Anorexia 0 0 0 Gait disturbance 0 0 0
Fatigue 1 0 0 Memory impairment 0 0 0
Somnolence 1 0 0 Tremors 0 0 0
Weakness 1 0 0 Cerebral edema 0 0 0
HEENT Hydrocephalus 0 0 0
Eye paralysis, lateral 0 0 0 Infectious
Gastrointestinal Urinary tract infection 0 0 0
Nausea 0 0 0 Laboratory test results
Diarrhea 0 0 0 Elevated ALT 0 0 0
Constipation 0 0 0 Elevated AST 0 0 0
Vomiting 0 0 0 Hyperbilirubinemia 0 0 0
Cardiac Hyperkalemia 0 0 0
Bradycardia 0 0 0 Hypernatremia 0 0 0
Hyponatremia 0 0 0