Table 2.
Analytical performances of anti-cetuximab IgE detection by ELISA or FEIA in the severe HSR group of the retrospective cohort. In bold, likelihood ratios over 10 which were considered significant
| ELISA Mariotte D. et al. 2011 [17] | FEIA ImmunoCAP o215 | |||
|---|---|---|---|---|
| Threshold | > 29 EAU | > 0.1 kUA/L (defined by the manufacturer) | ≥ 0.35 kUA/L (commonly accepted threshold for sensitization) | ≥ 0.525 kUA/L (defined by the ROC curve) |
| Se (%) | 87.5 | 87.5 | 87.5 | 87.5 |
| Sp (%) | 82.1 | 93.9 | 95.1 | 96.3 |
| PPV (%) | 33.3 | 58.3 | 63.6 | 70.0 |
| NPV (%) | 98.5 | 98.7 | 98.7 | 98.8 |
| pLR | 4.89a | 14.4 | 17.9 | 23.9 |
| nLR | 0.15a | 0.13 | 0.13 | 0.13 |
| pPP (%) | 19.6a | 44.0 | 49.6 | 56.7 |
| nPP (%) | 0.80a | 0.70 | 0.70 | 0.70 |
Abbreviations: EAU IgE arbitrary units, nLR Negative likelihood ratio, NPV Negative predictive value, nPP negative post-test probability, pLR Positive likelihood ratio, pPP Positive post-test probability, PPV Positive predictive value, Se Sensitivity, Sp Specificity
a Parameters not calculated in Mariotte 2011 study