Fig. 3.

Correlations between the CKD severity-related microbial species and functions. A Heatmap representation of spearman correlation between CKD severity-related microbial species and corresponding KEGG pathways. B Relative abundance of KO genes involved in arginine and proline metabolism, arachidonic acid metabolism, ubiquinone and other terpenoid-quinone biosynthesis, and glutathione metabolism that showed significant differences in at least one of CKD groups compared to the HC were shown in the heatmap (*P<0.05, **P<0.01, Wilcoxon rank-sum test). mod-CKD, moderate CKD; ESRD, end-stage renal disease