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. 2023 Jan 9;12:1. doi: 10.1186/s40035-022-00334-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — p85S6K expression is specifically decreased in human AD brains and 5×FAD mouse brains. a, b Expression of p85S6K/p70S6K and phosphorylated p85S6K in P2 pellets from fractionation of postmortem temporal cortex from human AD brains and non-demented control (Ctl). n = 13 for Ctl and n = 17 for AD. t = 0.8582, df = 27, P = 0.3984 for p-p85S6K, Mann–Whitney U = 39, P = 0.0021 for p85S6K, Mann–Whitney U = 107, P = 0.9016 for p70S6K. c Pearson correlation of Braak stage and the expression level of p85S6K in human brains. d–f Expression of p85S6K/p70S6K and phosphorylated p85S6K in P2 pellets from fractionation of cortex (d, e) and hippocampus (d, f) from 7-month-old 5×FAD mice. n = 4 mice per group. t = 0.9933, df = 6, P = 0.3589; t = 4.005, df = 6, P = 0.0238; t = 0.7484, df = 6, P = 0.4825 (e, from left to right panels). t = 0.9035, df = 6, P = 0.4011; t = 3.548, df = 6, P = 0.0121; t = 2.221, df = 6, P = 0.0681 (f, from left to right panels). Data are presented as mean ± SEM. Mann–Whitney test, two-tailed (b, middle and right panels) and unpaired t test, two-tailed (b, left panel; and e, f). *P < 0.05, **P < 0.01