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. 2023 Jan 9;21:10. doi: 10.1186/s12951-023-01767-9

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© The Author(s) 2023, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Histological changes in injured sciatic nerve with the treatment of EC-EXO. A Representative images of HE and Masson staining sciatic nerve longitudinal and cross sections in sham, PNI and EXO groups 28 days following the treatment of EC-EXO (n = 3). Scale bar, 20 μm. B Representative images of toluidine blue (TB) staining sciatic nerve in each group (n = 3). Scale bar, 20 μm. C Representative TEM images of sciatic nerve in each group (n = 3). Scale bar, 10, 2 and 1 μm. D Statistical analysis of the number of axons with myelin. The data are expressed as mean ± SD (n = 3). E Statistical analysis of the thickness of myelin sheath. The data are expressed as mean ± SD (n = 3). F Statistical analysis of G-ratio; The data are expressed as mean ± SD (n = 3). ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001