During the last two decades there have been efforts, using various microbes and effectors, to combat different pathogens in specific mosquito species; these studies are summarized in this figure. Certain trends can be seen, including the use of better symbionts, exploring stronger effectors, and designing more efficient expression-delivery methods. See [29,30,61,64,66,75–77,83,84,87,99,101,102,104,106].