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. Author manuscript; available in PMC: 2023 Jan 9.
Published in final edited form as: Biol Psychiatry. 2022 May 17;92(9):739–749. doi: 10.1016/j.biopsych.2022.05.012

Figure 1.

Figure 1.

2MT induces freezing to and avoidance of the odor source. (A) Schematic of 2MT (n = 25) or H2O: (n = 25) (no odor control) exposure. Two-way analysis of variance (B, D, I, J) or unpaired t test (C, E, F) performed and effects of interaction shown. (B) 2MT decreases distance traveled during the beginning of the exposure test. (C) 2MT has no effect on total distance traveled. (D) 2MT increases time spent freezing over duration of test. (E) 2MT increases the total time spent freezing during exposure. (F) 2MT increases freezing frequency. (G) Schematic of the zones that the testing apparatus is divided into to assess avoidance of the odor source. (H) Representative heat map of time spent in different zones of mouse exposed to H2O (left) and 2MT (right). (I) 2MT-exposed mice spend significantly less time in the odor zone and more time in the far zone, with no change in the middle zone. (J) 2MT-exposed mice travel significantly less around the odor zone and more in the far zone. *p < .05; **p < .01; ***p < .001; ****p < .0001. 2MT, 2-methyl-2-thiazoline; F, far zone; M, middle zone; O, odor zone.