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. 2022 Mar 2;54(4):565–573. doi: 10.3724/abbs.2022021

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).

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Ets1 participates in high glucose-mediated endothelial inflammation via upregulation of PTP1B expression

(A) The protein expressions of ets1, PTP1B, VCAM-1 and p65 phosphorylation in HUVECs with corresponding treatments. (B) The mRNA expression of ets1 in HUVECs with corresponding treatments. (C) The mRNA expression of PTP1B in HUVECs with corresponding treatments. (D) The mRNA expression of VCAM-1 in HUVECs with corresponding treatments. (E) Monocyte/endothelial adhesion with corresponding treatments. (F) Ets1 was enriched in the PTP1B promoter region. (G) The putative ets1-binding site in PTP1B. The motif logo and position weight matrix were listed in the up and down panel, respectively. (H,I) PTP1B promoter activity was tested by luciferase reporter assays. **P<0.01, ***P<0.001, ****P<0.0001.