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. 2022 Oct 10;18(5):996–1003. doi: 10.4103/1673-5374.355748

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Copyright: © Neural Regeneration Research

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Schematic overview of the NO/cGMP signaling pathway.

L-arginine is decomposed by NOS, generating NO. NO activates soluble guanylate cyclase, leading to subsequent cGMP production. Natriuretic peptides binding to pGC is another source of cGMP. cGMP then further activates PKG, PDEs, and CNG. The main effector of cGMP is PKG. PKG has multiple targets, including CRP2 and K⁺_ATP. PKG also participates in presynaptic nociceptive LTP. cGMP: Cyclic guanosine 3’,5’-monophosphate; CNG: cyclic nucleotide-gated channel; CRP2: cysteine-rich protein 2; K⁺_ATP: ATP-sensitive K⁺ channel; LTP: long-term potentiation; NO: nitric oxide; NOS: nitric oxide synthase; PDE: phosphodiesterase; pGC: particulate guanylyl cyclase; PKG: cGMP-dependent protein kinase; sGC: soluble guanylyl cyclase.