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. 2022 Oct 10;18(5):1099–1106. doi: 10.4103/1673-5374.355815

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Copyright: © Neural Regeneration Research

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Double immunofluorescence staining for IGF-2 in the midbrain region of a mouse model of PD.

Midbrains from the ipsilateral and contralateral sides of mice with 6-OHDA-induced lesions were subjected to immunohistofluorescence. IGF-2 (green, Alexa Fluor-488) was expressed in TH-positive cells (red, Alexa Fluor-568), Tuj1-positive neurons (red, Alexa Fluor-568), and GFAP-positive neurons (red, Alexa Fluor-568). Compared with the intact side, there were fewer TH-positive neurons and Tuj1-positive neurons and more GFAP-positive neurons on the lesioned side. Scale bars: 50 μm (upper four rows) and 10 μm (lowest row). GFAP: Glial fibrillary acidic protein; IGF-2: insulin-like growth factor-2; PD: Parkinson’s disease; TH: tyrosine hydroxylase; TUJ1: β3 tubulin.