Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 10;18(5):1107–1117. doi: 10.4103/1673-5374.355816

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Neural Regeneration Research

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

PMC Copyright notice

Linear correlation analysis and receiver operating characteristic (ROC) curve analysis for predicting the degree of cognitive impairment.

(A, B) A positive linear correlation (Spearman correlation) was observed between the Mini-Mental State Examination (MMSE) score and glial cell line-derived neurotrophic factor (GDNF) (A) and between the Montreal Cognitive Assessment (MoCA) score and GDNF (B). The oblique line represents the linear relationship. The linear regression equations are listed respectively. Ellipses of different colors represent different subgroups. The long axis of the ellipse represents the linear relationship of each subgroup. (C, D) The single serum GDNF indicator and the composite index predicted the ROC curve for varying degrees of cognitive impairment based on cognitive evaluations using the MMSE (C) and MoCA (D). Combination 1: education, Parkinson’s disease (PD) duration, Hoehn-Yahr stage, and levodopa equivalent daily dose (LEDD) combined with serum GDNF; Combination 2: PD duration, Hoehn-Yahr stage, LEDD, and alcohol consumption combined with serum GDNF; Combination 3: PD duration, Hoehn-Yahr stage, LEDD, alcohol consumption, sex, age, education, high blood pressure, diabetes, and smoking combined with serum GDNF. GDNF: Glial cell derived neurotrophic factor; LEDD: levodopa equivalent daily doses; MMSE: min-mental state examination; MoCA: Montreal cognitive assessment; PD: Parkinson’s disease.