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Glial scar formation after SCI.
The figure displays the two injury types, primary and secondary, conceived from a sectioning of SCI. Microglia are activated in the secondary injury process and induce inflammation at the lesion site, promoting the production of glial scar formation. Astrocytes begin forming astrocytic scar tissue and fibroblasts develop fibroblastic scars. Ultimately this leads to axonal damage and neuronal death if left untreated. SCI: Spinal cord injury.
