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. 2022 Oct 10;18(5):991–995. doi: 10.4103/1673-5374.355750

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Copyright: © Neural Regeneration Research

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Importance of mitochondria homeostasis in AD and PD.

The most promising mitostasis therapeutic targets in neurodegeneration are highlighted in green. Dashed arrows represent lesser impacts in degeneration pathways and solid arrows represent main action mechanisms. Blue boxes represent the known clinical representations of PD and AD in mitochondria with a causational hypothesis in the literature (Cheng and Bai, 2018). AD: Alzheimer’s disease; Aβ: amyloid β peptide; DJ-1: protein/nucleic acid deglycase DJ-1; GBA: glucocerebrosidase; HSPA9: stress-70 protein, mitochondrial; LRRK2: leucine-rich repeat kinase 2; PD: Parkinson’s disease; PINK1: mitochondrial serine/threonine-protein kinase; PRKN: E3 ubiquitin-protein ligase parkin; RHOT1: mitochondrial Rho GTPase 1; tau: microtubule-associated tau protein; TRAP1: heat shock protein 75 kDa, mitochondrial.