Figure 4 .

Products and byproducts generated during genome editing

In addition to small indels (top left), vector DNA from plasmid or virus can be integrated into the target site. ITR elements from AAV have been reported to function as enhancers (top right). The juxtaposition of two DSBs forms chromosomal translocations. Both DSBs frequency and spatial distance contribute to the translocation formation (bottom left). Large deletions are generated by end-joining after extensive DNA resection at the target site (bottom right).