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. 2022 Oct 13;17(22):e202200393. doi: 10.1002/cmdc.202200393

Table 3.

Activity of compounds 15–26 against P. falciparum 3D7 strain.[a]

graphic file with name CMDC-17-0-g002.jpg

Cpd

X

Y

Z

Q

R1

R2

R3

3D7 IC50 [μM]

15

C

C

C

N

H

H

H

4.4±0.59

16

C

C

C

C

OCH3

H

H

1.2±1.2

17

C

C

C

C

H

H

Cl

0.6±0.09

18

O

C

C

C

H

H

H

6.8±0.75

19

C

C

C

C

H

CN

H

>10

20

C

C

C

C

H

Cl

H

>25

21

C

C

C

C

H

OCH3

H

>25

22

C

C

C

C

CN

H

H

>25

23

C

C

C

C

Cl

H

H

>25

24

C

N

C

C

H

H

–

10.2±0.75

25

C

C

N

C

H

–

H

10.8±0.65

26

C

C

C

C

H

H

OCH3

>10.0

[a] Values reported are geometric mean ± SEM of at least two independent experiments.