Table 6.

In vitro intraerythrocytic antimalarial activity of 2 against field adapted strains (chloroquine and artesunate as controls).^[a]

Field adapted strain	Mutated loci	Compound 2, IC50 [μM][b] (fold shift)	Chloroquine IC50 [μM][b]	Artesunate IC50 [μM][b]
NF54		0.55 (−)	0.008	0.004
K1	Pfcrt, Pfmdr1, Pfdhfr, Pfdhps	0.62 (1.1)	0.20	0.002
7G8	Pfcrt, Pfmdr1, Pfdhfr, Pfdhps	0.47 (0.8)	0.08	0.002
TM90 C2b	Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, PfcytbQ0	0.72 (1.3)	0.14	0.005
Cam3.I	Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, Pfkelch13	0.79 (1.4)	0.18	0.011
Dd2	Pfcrt, Pfmdr1, Pfdhfr, Pfdhps	0.90 (1.6)	0.16	0.006

[a] 72‐hour [³H]hypoxanthine incorporation assay. [b] mean values from two independent biological replicates.