FIGURE 2.

Biogenesis of small extracellular vesicle (sEV) and mechanisms of lncRNA sorting into EVs. (A) sEV generated from multivesicular body fusion with the plasma membrane or direct budding from the plasma membrane; (B) HnRNPA2B1 was shown to guide lncRNA sorting into sEVs by directly binding to stemloops or binding specific sequence motifs. (C) LncRNAs packaging into EV are important to exert their optimal functions. Left, EV protect lncRNAs from degradation by RNase; Right, EV help lncRNAs recognize targeted cells