Table 3.
Independent risk factors associated with subclinical RA‐ILD in the discovery population (ESPOIR)*
| Model with MUC5B r35705950 | Categorized model with MUC5B rs35705950 | Model without MUC5B rs35705950 | Categorized model without MUC5B rs35705950 | Weighted coefficient without MUC5B rs35705950 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P † | OR (95% CI) | P † | Weighted coefficient with MUC5B rs35705950 | OR (95% CI) | P † | OR (95% CI) | P † | ||
| MUC5B rs35705950 | ||||||||||
| GG | 1 (referent) | 1 (referent) | 0 | NA | NA | NA | NA | NA | ||
| GT/TT | 3.74 (1.37–10.39) | 0.01 | 3.52 (1.28–9.77) | 0.01 | 27 | NA | NA | NA | NA | NA |
| Sex | ||||||||||
| Female | 1 (referent) | 1 (referent) | 0 | 1 (referent) | NA | NA | 0 | |||
| Male | 3.93 (1.40–11.39) | 0.01 | 3.59 (1.26–10.42) | 0.02 | 28 | 3.8 (1.4–10.6) | <0.01 | NA | NA | 28 |
| Age at RA onset | ||||||||||
| Per year change | 1.10 (1.04–1.16) | <0.001 | – | 1.1 (1.0–1.2) | 0.001 | – | ||||
| ≤49 years | – | 1 (referent) | 0 | – | 1 (referent) | 0 | ||||
| 50–58 years | – | 3.10 (1.08–9.66) | 0.04 | 25 | – | 2.68 (0.97–7.89) | 0.06 | 21 | ||
| >58 years | – | 9.98 (3.04–36.36) | <0.001 | 50 | – | 8.81 (2.8–30.09) | <0.001 | 47 | ||
| Mean DAS28‐ESR | ||||||||||
| Per unit change | 2.03 (1.24–3.42) | 0.006 | – | 1.9 (1.2–3.2) | 0.01 | – | ||||
| <2.9 | – | 1 (referent) | 0 | – | 1 (referent) | 0 | ||||
| 2.9–4.3 | – | 2.83 (1.02–8.46) | 0.05 | 23 | – | 2.54 (0.94–7.36) | 0.07 | 20 | ||
| >4.3 | – | 5.93 (1.45–24.78) | 0.01 | 39 | – | 5.93 (1.4–23.47) | 0.01 | 38 | ||
*
A categorized model is a model in which continuous variables are transformed into categorical variables. NA = not applicable. See Table 1 for other definitions.
†
Results from the multivariate analysis.