| ISUP grade group | Gleason score | Risk for clinically significant prostate cancer |
|---|---|---|
| 1 | ≤ 6 | Low risk |
| 2 | 3 + 4 = 7 | Intermediate favourable risk |
| 3 | 4 + 3 = 7 | Intermediate unfavourable risk |
| 4 | 8 (4 + 4 or 3 + 5 or 5 + 3) | High risk |
| 5 | 9–10 (4 + 5 or 5 + 4 or 5 + 5) | Highest risk |