Localised			Locally advanced
Low risk	Intermediate risk	High risk	High risk
PSA < 10 ng/mL and GS < 7 (ISUP grade group 1) and cT1‐2a	PSA 10–20 ng/mL or GS 7 (ISUP grade group 2/3) or cT2b	PSA > 20 ng/mL or GS > 7 (ISUP grade group 4/5) or cT2c	Any PSA, any GS (any ISUP grade group) cT3‐4 or cN+

cN + = lymph node positive; cT1‐2a = cancer present but not detectable on digital rectal examination (DRE) or imaging, or is palpable on DRE but is organ‐confined to half or less than half of one lobe of the prostate; cT2b = tumour‐confined to more than one half of one gland of prostate but not both; cT2c = tumour is in both lobes of the prostate but within the prostate capsule; cT3‐4 = locally extensive cancer that penetrates the prostate capsule, or invades into the seminal vesicle, or invades into the bladder neck/rectum/external urinary sphincter; GS = Gleason score; ISUP = International Society for Urological Pathology; PSA = prostate‐specific antigen.