ISUP grade group	Management options
1	Active surveillance if life expectancy > 10 years Watchful waiting if life expectancy < 10 years In higher risk patients (eg, those with BRCA2 mutations) may still consider radical prostatectomy or radiotherapy
2	Prostatectomy or radiotherapy † Could consider active surveillance in patients with < 10% Gleason pattern 4 with favourable PSA, until life expectancy < 10 years
3	Prostatectomy or radiotherapy †
4	Prostatectomy or radiotherapy †
5	Prostatectomy or radiotherapy †

ISUP = International Society for Urological Pathology; PSA = prostate‐specific antigen.

^*Focal therapy remains an emerging experimental modality and is currently only recommended for use in clinical trial setting.

^†Discussing androgen deprivation therapy (ADT), which can be given with radiotherapy.