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. 2022 Oct 5;61(44):e202210508. doi: 10.1002/anie.202210508

Scheme 5.

Scheme 5

Upscaling the mechanochemical nickel‐catalyzed Suzuki–Miyaura coupling via twin‐screw extrusion. A) In depth protocol design. B) Pictorial representation of extrusion run. C) Results from the 100 mmol‐scale extrusion process including data on throughput rate and space time yield (STY).