Table 2.
Levels of inflammatory markers according to sex and age group
| Age, y | |||||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| 20–39 | 40–49 | 50–64 | 65–74 | 75–84 | 85 + | P * | |
| n | |||||||
| Men | 56 | 29 | 48 | 48 | 138 | 48 | NA |
| Women | 61 | 26 | 54 | 301 | 196 | 93 | NA |
| IL-6, pg/mL † | |||||||
| Men | 0.6 (0.4-0.8) | 0.9 (0.7-1.3) | 1.1 (0.9-1.4) | 1.4 (1.2-1.5) | 1.8 (1.6-2.1) | 3.5 (2.6-4.7) | < .0001 |
| Women | 0.6 (0.5-0.8) | 0.8 (0.6-1.1) | 0.8 (0.7-1.0) | 1.1 (1.1-1.2) | 1.5 (1.4-1.7) | 2.1 (1.7-2.6) | < .0001 |
| sIL-6r, ng/mL † | |||||||
| Men | 93 (79-108) | 77 (61-97) | 88 (73-105) | 91 (85-97) | 92 (85-99) | 96 (82-111) | .42 |
| Women | 76 (67-87) | 81 (65-101) | 83 (70-97) | 91 (84-95) | 92 (86-97) | 97 (88-106) | .003 |
| IL-1β, pg/mL † | |||||||
| Men | 0.12 (0.10-0.15) | 0.18 (0.13-0.36) | 0.18 (0.12-0.20) | 0.13 (0.12-0.15) | 0.12 (0.10-0.14) | 0.12 (0.10-0.14) | .26 |
| Women | 0.14 (0.12-0.18) | 0.15 (0.11-0.19) | 0.15 (0.11-0.18) | 0.12 (0.11-0.14) | 0.13 (0.12-0.16) | 0.14 (0.11-0.17) | .64 |
| IL-1ra, pg/mL † | |||||||
| Men | 112 (100-125) | 143 (117-172) | 137 (115-164) | 133 (124-141) | 135 (119-152) | 154 (131-180) | < .05 |
| Women | 114 (96-135) | 125 (97-158) | 117 (100-137) | 125 (117-134) | 144 (133-154) | 145 (130-160) | < .001 |
| TNF-α, pg/mL † | |||||||
| Men | 4.8 (3.8-6.1) | 4.0 (2.8-5.6) | 6.2 (4.8-8.0) | 4.6 (4.1-5.0) | 4.4 (3.8-5.0) | 5.1 (4.0-6.4) | .50 |
| Women | 4.8 (3.6-6.4) | 3.8 (2.7-5.4) | 5.0 (4.1-6.1) | 4.4 (4.0-4.9) | 4.6 (4.1-5.1) | 5.1 (4.3-6.0) | .76 |
| IL-18, pg/mL † | |||||||
| Men | 335 (303-369) | 319 (285-356) | 400 (358-447) | 420 (403-436) | 435 (411-459) | 454 (417-493) | < .0001 |
| Women | 268 (245-292) | 292 (253-336) | 325 (300-352) | 340 (325-353) | 357 (340-373) | 430 (392-470) | < .0001 |
| TGF-β, ng/mL | |||||||
| Men | 14.7 (12.7-16.7) | 10.2 (7.9-12.6) | 12.4 (10.6-14.1) | 11.9 (11.1-12.8) | 11.2 (10.0-12.4) | 13.9 (11.9-15.8) | .12 |
| Women | 12.6 (11.0-14.1) | 12.1 (9.7-14.5) | 11.7 (9.9-13.4) | 11.2 (10.4-11.9) | 13.0 (11.8-14.2) | 12.3 (10.8-13.7) | .69 |
| CRP, g/L † | |||||||
| Men | 1.0 (0.8-1.4) | 1.9 (1.1-3.2) | 1.8 (1.3-2.5) | 2.6 (2.2-2.9) | 3.1 (2.6-3.7) | 5.4 (3.8-7.9) | < .0001 |
| Women | 1.1 (0.8-1.5) | 1.1 (0.6-1.8) | 2.3 (1.8-2.9) | 2.5 (2.2-2.8) | 3.0 (2.6-3.5) | 3.3 (2.6-4.3) | < .0001 |
| Fibrinogen, mg/mL | |||||||
| Men | 269 (254-284) | 321 (290-352) | 315 (296-333) | 345 (335-354) | 345 (331-357) | 396 (372-419) | < .0001 |
| Women | 317 (303-331) | 324 (302-345) | 352 (337-367) | 354 (346-361) | 370 (359-379) | 398 (381-415) | < .0001 |
Values are reported as means and 95% confidence intervals. NA indicates not applicable.
*
Tests for trend from general linear models.
†
Means and 95% confidence intervals were calculated from log-transformed values that were then back-transformed for data presentation.