Figure 4.

Progression of structural damage (EXTRAP). A, Least squares (LS) mean change from baseline to week 24 in Sharp/van der Heijde (SHS) score, joint space narrowing (JSN) scores, and erosion scores. Statistical comparisons were determined by analysis of covariance using the status of prior tumor necrosis factor inhibitor usage and baseline values as covariates. B, Cumulative probability of change in SHS score at week 24 compared with baseline values. Percentages indicate rates of nonprogression (ΔSHS ≤0) in each treatment group. P values were calculated by chi‐square test without continuity correction or multiplicity adjustment. MTX = methotrexate.