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. 2022 Sep 25;112(6):1243–1253. doi: 10.1002/cpt.2736

Figure 4.

Figure 4

The level of evidence available regardless of age in each ATC level 1 group. The number of records for each ATC group is listed between brackets; ATC level 1: A: Alimentary tract and metabolism; B: Blood and blood forming organs; C: Cardiovascular system; D: Dermatologicals; G: Genito‐urinary system and sex hormones; H: Systemic hormonal preparations, excluding sex hormones and insulins; J: Anti‐infectives for systemic use; L: Antineoplastic and immunomodulating agents; M: Musculoskeletal system; N: Nervous system; P: Antiparasitic products, insecticides and repellents; R: Respiratory system; S: Sensory organs; V: Various. Y‐axis: Level of evidence: A0: Authorized use; A1: systematic review or meta‐analysis with at least two studies of level A2; A2: randomized controlled trial with at least 4 points on the Jadad scale; B: comparative research with a maximum of 3 on the Jadad scale; C: noncomparative research; D: consensus or expert opinion; X: Selected guidelines (HIV, oncology, and metabolic diseases). Blue bars represent high level of evidence (level A1 and A2). Orange bars represent low level of evidence (B, C, and D). ATC, Anatomical Therapeutic Chemical; RCT, randomized controlled trial.