Figure 2 .

Nucleotide excision repair in chromatin environment

(A) Chromatin factors that may affect NER, including histone modifications, transcription, transcription factor binding, nucleosome positioning and genome accessibility. TF is short for transcription factor. (B) The methodology to map NER across the genome. The indirect strategy measures genomic profiles of damage at different time points and acquires the pattern of accumulated repair during this time course by comparing damage profiles. The direct strategy (XR-seq) maps NER by capturing and sequencing excised oligonucleotides and obtains the snapshot of repair at a specific time point.