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. 2022 Feb 16;54(4):574–582. doi: 10.3724/abbs.2022017

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).

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MiR-146a-5p in TCs decreases oxidative stress both in vitro and in vivo

(A) MDA levels in the lung tissue of ARDS mice were increased, and decreased in the telocyte-treated group. MDA levels were increased again when infused with telocytes pretreated with antagomiR-146a-5p. (B,C) MDA levels in the TCs and culture media were decreased when treated with LPS, and increased again when treated with antagomiR-146a-5p. Both KG-501 and 666-15 reduced the MDA level in TCs silenced with antagomiR-146a-5p. Data are shown as the mean±standard deviation from six independent experiments (n=6). *P< 0.05.