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. 2022 Oct 19;61(47):e202207551. doi: 10.1002/anie.202207551

Figure 3.

Figure 3

A) General scheme of synthesis of DABCYL derivatives linked to cyclic deca‐arginine (cR10DX, X=1–13). B) General scheme of activated CPP (cR10DX‐TNP) synthesis. C) Synthesis of TAMRA labeled Ub in CPP‐Ub conjugates (TAMRA‐Ub‐ss‐cR10DX). D) Analytical HPLC and mass analysis of purified Azido‐DABCYL conjugated cyclic deca‐arginine (cR10D11) with the observed mass 2645.4±0.6 Da, calcd 2646 Da (average isotopes). E) Analytical HPLC and mass analysis of purified TAMRA‐Ub‐ss‐cR10D11 (Ub11). HPLC chromatogram detected at 214 nm.