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Different patterns of progressive disease (PD): (A) Conventionally defined PD, according to IMWG criteria, (B) Modified PD, according to IMWG criteria integrated with sFLC data and including a new subcategory of sFLC PD defined by an increase in sFLC either combined with conventional IMWG criteria of PD or as sFLC escape. M‐Ig, monoclonal immunoglobulin; PD, progressive disease; sFLC, serum‐free light chain. [Color figure can be viewed at wileyonlinelibrary.com]
