Table 2.
Univariate Cox analysis for disease-free survival in all available patients.
| Characteristics | n | Events | HR (95%CI) | Wald P | Log-rank P | |
|---|---|---|---|---|---|---|
| Age (years) | <65 | 90 | 10 | reference | ||
| ≥65 | 23 | 7 | 2.99 (1.14–7.86) | 0.026 | 0.02 | |
| Gender | Male | 66 | 11 | reference | ||
| Female | 47 | 6 | 0.78 (0.29–2.12) | 0.632 | 0.631 | |
| Cancer type | Colon | 106 | 17 | reference | ||
| Rectal | 7 | 0 | 0.04 (0–211.67) | 0.472 | 0.272 | |
| Tumor site† | Right | 58 | 9 | reference | ||
| Left | 55 | 8 | 0.93 (0.36–2.41) | 0.876 | 0.876 | |
| T Stage | T3 | 103 | 15 | reference | ||
| T4 | 10 | 2 | 1.5 (0.34–6.55) | 0.592 | 0.589 | |
| Differentiation | Mod/Well | 83 | 14 | reference | ||
| Poor | 30 | 3 | 0.61 (0.18–2.13) | 0.438 | 0.434 | |
| Mucinous | No | 107 | 16 | reference | ||
| Yes | 6 | 1 | 1 (0.13–7.53) | 0.999 | 0.999 | |
| Examined LN | <12 | 11 | 2 | reference | ||
| ≥12 | 102 | 15 | 0.76 (0.17–3.35) | 0.72 | 0.719 | |
| VELIPI | No | 85 | 12 | reference | ||
| Yes | 28 | 5 | 1.4 (0.49–3.96) | 0.532 | 0.53 | |
| Clinical risk | Low | 64 | 9 | reference | ||
| High | 49 | 8 | 1.16 (0.45–3.02) | 0.755 | 0.755 | |
| MMR status | pMMR | 100 | 16 | reference | ||
| dMMR | 13 | 1 | 0.47 (0.06–3.58) | 0.47 | 0.459 | |
| Preoperative CEA | <5 ng/ml | 77 | 10 | reference | ||
| ≥5 ng/ml | 35 | 6 | 1.44 (0.52–3.96) | 0.481 | 0.479 | |
| Modified IS 2-groups | Int+Lo | 70 | 17 | reference | ||
| Hi | 43 | 0 | 0.02 (0–1.12) | 0.057 | 0.001 | |
| Classical IS 2-groups | Lo | 8 | 4 | reference | ||
| Hi+Int | 105 | 13 | 0.21 (0.07–0.64) | 0.002 | 0.006 | |
| IS 3-groups (numeric) | - | - | 0.2 (0.09–0.44) | <0.0001 | ||
†Left-sided cancer was defined as tumors arising from the splenic flexure, descending, sigmoid, rectosigmoid colon, or the rectum; right-sided cancer was defined as tumors arising from the cecum, ascending, hepatic flexure, or transverse colon.