TABLE 2.

Combined analysis using InterLymph, IMMEnSE and FinnGen results

SNP	Region	(Alleles) M/m a	InterLymph		IMMEnSE		FinnGen		Combined analysis
			OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	I 2 b	Q b	Q‐P value
rs34517439	1p31.1	C/A	1.30 (1.15‐1.48)	4.70 × 10−5	1.09 (0.89‐1.34)	.402	1.21 (1.09‐1.34)	.071	1.22 (1.13–1.32)	4.81 × 10 −7	7.30%	2.25	.325
rs6674512	1p22.3	G/A	1.40 (1.21‐1.62)	8.71 × 10−6	1.10 (0.88‐1.36)	.402	1.04 (0.91‐1.20)	.765	1.17 (0.96‐1.43)	.115	77.50%	9.74	.008
rs10187103	2q24.3	C/T	0.84 (0.77‐0.91)	6.06 × 10−5	0.99 (0.88–1.12)	.915	0.99 (0.90‐1.09)	.924	0.95 (0.83–1.08)	.397	81.10%	10.38	.006
rs1022206	3q13.13	C/T	1.18 (1.09‐1.28)	8.61 × 10−5	1.11 (1.00–1.24)	.061	0.99 (0.92‐1.07)	.923	1.09 (0.97‐1.22)	.136	80.00%	10.25	.006
rs4143832	5q31.1	G/T	1.24 (1.12‐1.37)	4.66 × 10−5	0.95 (0.83–1.08)	.439	0.91 (0.84‐0.99)	.275	1.02 (0.84‐1.25)	.819	91.30%	22.96	1.03 × 10−5
rs537930	5q31.1	G/T	0.83 (0.76‐0.91)	5.09 × 10−5	0.97 (0.86–1.09)	.571	0.96 (0.88‐1.04)	.596	0.92 (0.83‐1.01)	.088	70.10%	6.51	3.80 × 10−2
rs1063348	6p21.32	G/A	1.19 (1.09‐1.30)	7.44 × 10−5	0.95 (0.85–1.07)	.398	NA c	NA	1.07 (0.87‐1.32)	.534	89.6%	14.49	.001
rs13252276	8p23.1	C/T	0.77 (0.68‐0.87)	3.10 × 10−5	1.01 (0.91–1.12)	.870	1.03 (0.96‐1.11)	.711	0.93 (0.79–1.10)	.415	88.00%	17.50	2.00 × 10−4
rs465530	12q14.3	G/T	1.18 (1.09–1.28)	4.94 × 10−5	1.01 (0.89–1.13)	.926	0.95 (0.88‐1.02)	.458	1.03 (0.90‐1.19)	.657	87.80%	17.06	2.00 × 10−4
rs8132680	21q22.12	T/C	1.21 (1.11‐1.33)	2.96 × 10−5	0.99 (0.88–1.12)	.924	1.04 (0.96‐1.13)	.646	1.08 (0.96‐1.21)	.197	77.40%	8.06	.018

^a M = the most common allele in controls; m = the less common allele in controls. The more common allele found in the control population has been used as reference and the other allele was defined as the exposure factor.

^b Measures of heterogeneity between the combined analysis components.

^c This polymorphism is not present in FinnGen, and therefore the combined analysis refers only to InterLymph and IMMEnSE populations.