TABLE 3.
Associations between MM risk and the top 10 SNPs in IMMEnSE population
| SNP | Region | (Alleles) M/m a | Allelic model b | Codominant model c | Dominant model d | Recessive model e | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR f | 95% CI | P value | OR het f | 95% CI | P value | OR hom f | 95% CI | P value | OR f | 95% CI | P value | OR f | 95% CI | P value | |||
| rs34517439 | 1p31.1 | C/A | 1.09 | 0.89‐1.34 | .402 | 1.10 | 0.88‐1.38 | .395 | 1.09 | 0.44‐2.66 | .853 | 1.10 | 0.88‐1.37 | .387 | 1.07 | 0.44‐2.62 | .878 |
| rs6674512 | 1p22.3 | G/A | 1.10 | 0.88‐1.36 | .402 | 1.14 | 0.90‐1.44 | .267 | 0.74 | 0.24‐2.28 | .600 | 1.12 | 0.89‐1.41 | .320 | 0.73 | 0.24‐2.24 | .580 |
| rs10187103 | 2q24.3 | C/T | 0.99 | 0.88‐1.12 | .915 | 0.90 | 0.75‐1.07 | .215 | 1.09 | 0.83‐1.43 | .540 | 0.93 | 0.79‐1.10 | .407 | 1.15 | 0.89‐1.49 | .287 |
| rs1022206 | 3q13.13 | C/T | 1.11 | 1.00‐1.24 | .061 | 1.01 | 0.86‐1.20 | .889 | 1.29 | 1.03–1.62 | .028 | 1.08 | 0.92‐1.26 | .348 | 1.28 | 1.04–1.57 | .019 |
| rs4143832 | 5q31.1 | G/T | 0.95 | 0.83‐1.08 | .439 | 0.94 | 0.79–1.10 | .428 | 0.94 | 0.66‐1.32 | .709 | 0.94 | 0.80‐1.10 | .406 | 0.96 | 0.68‐1.35 | .807 |
| rs537930 | 5q31.1 | G/T | 0.97 | 0.86‐1.09 | .571 | 0.86 | 0.73‐1.00 | .061 | 1.14 | 0.84‐1.55 | .385 | 0.90 | 0.77‐1.05 | .168 | 1.22 | 0.90‐1.64 | .198 |
| rs1063348 | 6p21.32 | G/A | 0.95 | 0.85‐1.07 | .398 | 0.92 | 0.77‐1.10 | .368 | 0.92 | 0.72‐1.17 | .487 | 0.92 | 0.77‐1.09 | .336 | 0.96 | 0.77‐1.20 | .731 |
| rs13252276 | 8p23.1 | C/T | 1.01 | 0.91‐1.12 | .870 | 1.02 | 0.86‐1.21 | .825 | 1.01 | 0.82‐1.25 | .895 | 1.02 | 0.87‐1.19 | .826 | 1.00 | 0.83‐1.21 | .973 |
| rs465530 | 12q14.3 | G/T | 1.01 | 0.89‐1.13 | .926 | 0.83 | 0.67‐1.01 | .064 | 1.03 | 0.81‐1.31 | .820 | 0.89 | 0.73‐1.07 | .220 | 1.16 | 0.95‐1.42 | .147 |
| rs8132680 | 21q22.12 | T/C | 0.99 | 0.88–1.12 | .924 | 1.01 | 0.86‐1.19 | .869 | 0.96 | 0.72‐1.28 | .785 | 1.00 | 0.86‐1.17 | .960 | 0.96 | 0.72‐1.27 | .751 |
Note: In bold it is reported the statistically significant association.
a
M = the more common allele in controls; m = the less common allele in controls. The more common allele found in the control population has been used as the reference and the other allele was defined as the exposure factor.
b
Also termed quantitative additive (m vs M).
c
Mm vs MM (het) and mm vs MM (hom).
d
Mm + mm vs MM.
e
mm vs Mm + MM.
f
All the analyses were adjusted for age at diagnosis/recruitment, sex and country of origin. Results in bold show associations with P < .05.