|
Target |
BBB |
Tumor |
Ligand |
Transporter |
GLUT |
√ |
√ |
Glucose, Glucose analogues (2-deoxy-D-glucose), other hexoses (Mannose, Galactose, Glucosamine) |
GSH transporter |
√ |
× |
GSH |
LAT1 |
√ |
× |
Large neutral amino acids (L-tyrosine, L-phenylalanine, L-leucin, L-isoleucine) |
MCT1
|
√ |
× |
Lactate, Pyruvate, Biotin, Sialic acid |
Nucleoside transporter |
√ |
× |
Adenosine, Guanosine, Uridine |
Choline transporter |
√ |
× |
Choline, Thiamin |
Receptor |
TfR |
√ |
√ |
Tf, OX26, T7, TfR-lytic hybrid peptide |
LR |
√ |
√ |
Lf |
LDLR |
√ |
√ |
nLDL, Peptide-22 |
LRP |
√ |
√ |
Angiopep-2, MTf, ApoE, Peptide-22 |
Insulin Receptor |
√ |
√ |
83-14 murine monoclonal antibody |
Integrin αvβ3 |
√ |
√ |
RGD, c(RGDyK), cRGD |
EGFR |
√ |
√ |
GE11, EGF, mAb225 |
TGN receptor |
√ |
× |
TGN peptide |
CD44 |
× |
√ |
HA |
IL-13 Receptor |
× |
√ |
IL-13 |
FR |
× |
√ |
Folate, Pteroic acid |