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The commonly used enzymes and their substrates.
| Enzyme | Linker |
|---|---|
| Hyaluronidase | Hyaluronic acid (HA) |
| MMP-9 | GFFLGLDD peptide |
| MMP-2 | GPLGLAG peptide, GPLGVRGK peptide, PVGLIG peptide, GPLGVRGC peptide, VPLGVRTK peptide, PLGVRG peptide, Gelatin |
| Cathepsin B | GFLGKGLFG peptide, GFLG peptide , Val-Cit peptide, |
| FAP-α | DRGETGPAC peptide |
| β-glucuronidase | Glucuronide |
