FIG. 1.

(A) Clinical examination of nonimmunized and immunized rat corneas inoculated with cytotoxic P. aeruginosa strain 6206. Panels: a, nonimmunized rat corneas showing densely packed infiltrates that appeared as a ring in the periphery and mid-periphery of the cornea at 24 h postchallenge; b, orally immunized rat corneas (50%) showing dense infiltrates in the periphery of the cornea, with fewer infiltrates in the central cornea; c, nasally immunized rat corneas (25%) showing few focal infiltrates but diffuse infiltrates all over the anterior corneal stroma; d, IPP-immunized rat corneas (25%) showing dense infiltrates in the mid-periphery of the corneal stroma. (B) Composite clinical scores for nonimmunized and immunized rat corneas challenged with cytotoxic P. aeruginosa strain 6206 at various time points. Mean differences were considered significant when P was ≤0.05. C, nonimmunized; OI, orally immunized; NI, nasally immunized; IPP, IPP immunized.