TABLE 3.

Associations among caregiver outcomes and patient clinical characteristics

	Physical function		Pain		Fatigue		Depression		Anxiety		Caregiving burden		Treatment-related distress
	Day 90	Day 180	Day 90	Day 180	Day 90	Day 180	Day 90	Day 180	Day 90	Day 180	Day 90	Day 180	Day 90	Day 180
R 2	43%	41%	26%	0%	51%	51%	51%	55%	0%	0%	61%	51%	0%	56%**
Intercept	17.29*	24.22**	27.62*	52.51**	5.34	−2.72	5.64	20.72	54.00**	59.44**	0.39	1.56	11.05**	32.07**
Baseline caregiver outcome	0.65**	0.53**	0.52**	-	0.88**	1.01**	0.88**	0.76**	-	-	1.02**	0.85**	N/A	N/A
Number of hospital days	-	-	-	-	-	-	-	-	-	-	-		-	-
KPS ≥ 80a	-	-	-	-	-	-		−10.50*	-	-	-		-	−14.22**
High comorbidities HCT ≥ 3a	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CRS ≥ grade 2a	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Neurotoxicity ≥ grade 2a	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ICU admissiona	-	-	-	-	-	-	-	-	-	-	-	-	-	11.91*
Disease responsea	-	-	-	-	-	-		-	-	-			-	−13.43**

Notes: All clinical variables were introduced in each model. Baseline levels of caregiver outcomes were included in all models (i.e., baseline physical function as a predictor of physical function at day 90 and 180) with the exception of treatment-related distress, which was not assessed at baseline. As a guide to interpretation, R² indicates the percentage of variance in the outcome accounted by predictor variables, and the intercept indicates the outcome score at the assessment point. The estimates indicate differences in outcomes for each one unit increase of the predictor variable and empty rows indicate non-significant associations. Higher scores indicate worse caregivers' well-being, except for physical function, where higher scores indicate better well-being.

^a0 = no, 1 = yes.

^*p < 0.01

^**p < 0.001.