Table III.

Association of biomarkers and dysfunctional cerebral autoregulation by the HVP index

Autoregulation metrics	N babies	Unadjusted				Adjusted*
		β	95% CI		P	β	95% CI		P
			Lower	Upper			Lower	Upper
Tau same day
Mean HVP	47	1.42	−0.17	3.02	.083	1.08	−0.53	2.69	.192
Median HVP	47	0.59	−0.29	1.47	.189	0.45	−0.43	1.33	.316
Min HVP	47	0.15	−4.29	4.60	.946	−0.20	−4.62	4.22	.930
Max HVP	47	3.42	−8.97	15.80	.590	3.45	−8.93	15.83	.586
AUC HVP	47	0.0019	0.0005	0.0033	.010	0.0017	0.0003	0.0031	.022
Tau next day
Mean HVP	46	1.06	−0.60	2.72	.214	0.82	−0.80	2.44	.321
Median HVP	46	0.30	−0.63	1.22	.528	0.24	−0.66	1.13	.606
Min HVP	46	−1.05	−6.98	4.88	.729	−1.54	−7.35	4.27	.605
Max HVP	46	2.17	−9.94	14.28	.726	2.57	−9.28	14.42	.672
AUC HVP	46	0.0006	−0.0008	0.0020	.430	0.0006	−0.0008	0.0019	.426
GFAP same day
Mean HVP	48	−0.60	−2.06	0.86	.420	−0.79	−2.25	0.68	.294
Median HVP	48	−0.39	−1.18	0.39	.328	−0.46	−1.24	0.32	.253
Min HVP	48	−2.17	−5.79	1.45	.243	−2.28	−5.90	1.33	.218
Max HVP	48	−0.50	−11.89	10.90	.932	−0.58	−11.99	10.83	.921
AUC HVP	48	0.0001	−0.0012	0.0014	.917	−0.00003	−0.0013	0.0013	.966
GFAP next day
Mean HVP	46	1.02	−0.46	2.49	.180	0.88	−0.59	2.35	.243
Median HVP	46	0.36	−0.46	1.17	.391	0.31	−0.50	1.12	.455
Min HVP	46	−1.45	−6.47	3.57	.572	−1.59	−6.59	3.42	.536
Max HVP	46	1.59	−9.24	12.42	.774	1.40	−9.41	12.21	.800
AUC HVP	46	0.0003	−0.0009	0.0015	.609	0.0003	−0.0009	0.0015	.625
NRGN same day
Mean HVP	48	0.28	−0.80	1.36	.612	0.18	−0.91	1.27	.749
Median HVP	48	0.14	−0.44	0.73	.632	0.10	−0.48	0.69	.730
Min HVP	48	−0.68	−3.37	2.02	.624	−0.78	−3.47	1.90	.568
Max HVP	48	1.36	−7.02	9.75	.750	1.96	−6.43	10.36	.648
AUC HVP	48	0.00092	−0.00002	0.00186	.056	0.0009	−0.0001	0.0018	.072
NRGN next day
Mean HVP	46	0.39	−0.90	1.69	.552	0.31	−0.98	1.61	.636
Median HVP	46	0.19	−0.53	0.90	.609	0.17	−0.55	0.88	.648
Min HVP	46	−1.22	−5.72	3.28	.596	−1.59	−6.09	2.91	.490
Max HVP	46	1.47	−7.96	10.89	.761	2.51	−6.95	11.98	.604
AUC HVP	46	−0.00031	−0.00138	0.00076	.570	−0.0003	−0.0014	0.0007	.557

Bolded values denote statistical significance.

^*Adjusted for baseline encephalopathy (Sarnat score) and site.