Table 4:
Myocarditis rates following mRNA SARS-CoV-2 vaccination using 7- and 21-day risk windows by vaccine type, sex, and age*
| Risk window | Vaccine | Age group, yr | Rate per 100 000 doses (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Male | Female | |||||||
|
|
|
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| Dose 1 | Dose 2 | Dose 3 | Dose 1 | Dose 2 | Dose 3 | |||
| 7 days | Pfizer | 12–17 | 2.13 (0.44–6.24) | 6.73 (3.08–12.78) | 7.01 (1.45–20.49) | 0.00 (0.00–2.69) | 1.53 (0.19–5.53) | 0.00 (0.00–8.20) |
|
| ||||||||
| 18–29 | 0.36 (0.01–2.03) | 5.06 (2.70–8.66) | 2.98 (0.61–8.70) | 0.00 (0.00–1.30) | 1.13 (0.23–3.30) | 0.00 (0.00–2.96) | ||
|
| ||||||||
| 30–39 | 0.43 (0.01–2.40) | 0.46 (0.01–2.57) | 1.63 (0.04–9.08) | 0.00 (0.00–1.49) | 0.00 (0.00–1.58) | 0.00 (0.00–5.04) | ||
|
| ||||||||
| 40–49 | 0.00 (0.00–2.01) | 0.59 (0.01–3.27) | 1.86 (0.05–10.35) | 0.00 (0.00–1.76) | 0.51 (0.01–2.84) | 0.00 (0.00–5.37) | ||
|
| ||||||||
| 50–59 | 0.00 (0.00–1.99) | 1.20 (0.14–4.32) | 0.00 (0.00–6.02) | 0.00 (0.00–1.71) | 0.51 (0.01–2.82) | 0.00 (0.00–4.84) | ||
|
| ||||||||
| 60–69 | 0.00 (0.00–1.86) | 0.58 (0.01–3.24) | 0.00 (0.00–4.91) | 0.00 (0.00–1.61) | 0.50 (0.01–2.78) | 2.23 (0.27–8.07) | ||
|
| ||||||||
| 70–79 | 0.00 (0.00–2.27) | 0.00 (0.00–2.49) | 0.00 (0.00–4.95) | 0.00 (0.00–2.05) | 0.00 (0.00–2.23) | 0.00 (0.00–4.43) | ||
|
| ||||||||
| ≥ 80 | 0.00 (0.00–4.81) | 2.78 (0.34–10.03) | 0.00 (0.00–10.31) | 0.00 (0.00–3.62) | 0.00 (0.00–3.84) | 0.00 (0.00–8.15) | ||
|
| ||||||||
| Moderna | 12–17 | NA | NA | NA | NA | NA | NA | |
|
| ||||||||
| 18–29 | 0.90 (0.02–5.04) | 22.05 (14.13–32.81) | 3.95 (0.10–22.02) | 0.00 (0.00–3.81) | 1.00 (0.03–5.58) | 0.00 (0.00–9.59) | ||
|
| ||||||||
| 30–39 | 0.00 (0.00–3.82) | 6.99 (2.81–14.40) | 1.16 (0.03–6.48) | 0.00 (0.00–4.31) | 2.18 (0.26–7.87) | 1.00 (0.03–5.54) | ||
|
| ||||||||
| 40–49 | 0.00 (0.00–5.21) | 1.32 (0.03–7.33) | 0.00 (0.00–4.63) | 0.00 (0.00–5.67) | 0.00 (0.00–5.07) | 0.00 (0.00–3.91) | ||
|
| ||||||||
| 50–59 | 1.41 (0.04–7.85) | 0.00 (0.00–4.50) | 0.00 (0.00–3.77) | 0.00 (0.00–5.34) | 1.22 (0.03–6.79) | 0.00 (0.00–3.19) | ||
|
| ||||||||
| 60–69 | 0.00 (0.00–5.51) | 0.00 (0.00–4.21) | 0.00 (0.00–2.91) | 0.00 (0.00–5.34) | 0.00 (0.00–4.02) | 1.38 (0.17–4.97) | ||
|
| ||||||||
| 70–79 | 0.00 (0.00–9.13) | 0.00 (0.00–6.93) | 1.83 (0.22–6.62) | 0.00 (0.00–9.06) | 1.85 (0.05–10.3) | 0.00 (0.00–3.15) | ||
|
| ||||||||
| ≥ 80 | 0.00 (0.00–18.31) | 0.00 (0.00–14.87) | 0.00 (0.00–6.85) | 0.00 (0.00–13.47) | 0.00 (0.00–11.23) | 1.37 (0.03–7.64) | ||
|
| ||||||||
| 21 days | Pfizer | 12–17 | 2.85 (0.78–7.29) | 6.73 (3.08–12.78) | 9.35 (2.55–23.93) | 0.00 (0.00–2.69) | 1.53 (0.19–5.53) | 0.00 (0.00–8.20) |
|
| ||||||||
| 18–29 | 0.73 (0.09–2.63) | 5.84 (3.27–9.63) | 2.98 (0.61–8.70) | 0.35 (0.01–1.97) | 1.13 (0.23–3.30) | 0.00 (0.00–2.96) | ||
|
| ||||||||
| 30–39 | 2.59 (0.95–5.63) | 1.38 (0.29–4.05) | 3.26 (0.39–11.77) | 0.81 (0.10–2.92) | 0.43 (0.01–2.39) | 0.00 (0.00–5.04) | ||
|
| ||||||||
| 40–49 | 0.54 (0.01–3.03) | 1.17 (0.14–4.23) | 1.86 (0.05–10.35) | 0.00 (0.00–1.76) | 0.51 (0.01–2.84) | 1.46 (0.04–8.12) | ||
|
| ||||||||
| 50–59 | 1.08 (0.13–3.90) | 1.20 (0.14–4.32) | 1.63 (0.04–9.09) | 0.00 (0.00–1.71) | 1.52 (0.31–4.44) | 0.00 (0.00–4.84) | ||
|
| ||||||||
| 60–69 | 0.00 (0.00–1.86) | 0.58 (0.01–3.24) | 1.33 (0.03–7.41) | 0.44 (0.01–2.44) | 1.00 (0.12–3.60) | 2.23 (0.27–8.07) | ||
|
| ||||||||
| 70–79 | 0.00 (0.00–2.27) | 0.00 (0.00–2.49) | 0.00 (0.00–4.95) | 0.00 (0.00–2.05) | 0.61 (0.02–3.37) | 0.00 (0.00–4.43) | ||
|
| ||||||||
| ≥ 80 | 0.00 (0.00–4.81) | 2.78 (0.34–10.03) | 0.00 (0.00–10.31) | 0.98 (0.02–5.47) | 1.04 (0.03–5.80) | 2.21 (0.06–12.32) | ||
|
| ||||||||
| Moderna | 12–17 | NA | NA | NA | NA | NA | NA | |
|
| ||||||||
| 18–29 | 0.90 (0.02–5.04) | 22.97 (14.87–33.91) | 3.95 (0.10–22.02) | 0.00 (0.00–3.81) | 2.00 (0.24–7.23) | 0.00 (0.00–9.59) | ||
|
| ||||||||
| 30–39 | 2.07 (0.25–7.48) | 6.99 (2.81–14.40) | 1.16 (0.03–6.48) | 0.00 (0.00–4.31) | 3.27 (0.67–9.55) | 1.00 (0.03–5.54) | ||
|
| ||||||||
| 40–49 | 0.00 (0.00–5.21) | 1.32 (0.03–7.33) | 0.00 (0.00–4.63) | 0.00 (0.00–5.67) | 0.00 (0.00–5.07) | 0.00 (0.00–3.91) | ||
|
| ||||||||
| 50–59 | 2.82 (0.34–10.17) | 0.00 (0.00–4.50) | 0.00 (0.00–3.77) | 0.00 (0.00–5.34) | 1.22 (0.03–6.79) | 0.00 (0.00–3.19) | ||
|
| ||||||||
| 60–69 | 0.00 (0.00–5.51) | 0.00 (0.00–4.21) | 0.79 (0.02–4.40) | 0.00 (0.00–5.34) | 0.00 (0.00–4.02) | 2.06 (0.43–6.03) | ||
|
| ||||||||
| 70–79 | 0.00 (0.00–9.13) | 0.00 (0.00–6.93) | 1.83 (0.22–6.62) | 2.45 (0.06–13.68) | 1.85 (0.05–10.3) | 0.00 (0.00–3.15) | ||
|
| ||||||||
| ≥ 80 | 0.00 (0.00–18.31) | 0.00 (0.00–14.87) | 1.86 (0.05–10.34) | 0.00 (0.00–13.47) | 0.00 (0.00–11.23) | 1.37 (0.03–7.64) | ||
Note: CI = confidence interval, Moderna = mRNA-1273 (Moderna), NA = not applicable, OE = observed-to-expected, Pfizer = BNT162b2 (Pfizer-BioNTech).
*
Observed rates of myocarditis were calculated per 100 000 vaccine doses. Expected rates of myocarditis were expressed per 100 000 population.