Table 1:

Model parameters, including default values and ranges evaluated via grid sweep

Parameter*	Stratum	Value (range)	Source
Population size	Overall	100 000	Wang et al. 202117§
	Fraction in city A	0.50 (0.20–0.80)	§
Fraction at higher risk	City A	0.10 (0.01–0.50)¶	Wang et al. 202117§
	City B	0.10	Wang et al. 202117§
Contact rate	Close nonsexual, all	1	Milwid et al.18§
	Sexual, lower risk	0.01	Wang et al. 202117§
	Sexual, higher risk, city A	0.189** (0.10–0.25)¶	Wang et al. 2021,17§ Endo et al. 202219§
	Sexual, higher risk, city B	0.189**	Wang et al. 2021,17§ Endo et al. 202219§
Assortativity†	Cities, all contacts	0.90 (0.70–1.0)	Armstrong et al. 202020§
	Risk, close nonsexual	0	§
	Risk, sexual	0.50	§
Per-contact SAR	Close nonsexual	0.01††	Beer and Bhargavi Rao 2019,21 Thornhill et al. 202222
	Sexual	0.90**	Endo et al. 202219§
Initial infections	Overall	10	§
	Fraction in city A	0.50 (0–1.0)	§
Duration of period	Latent or incubation	8	Thornhill et al. 2022,22 Miura et al. 2022,23 Charniga et al. 2022,24 Guzzetta et al. 202225
	Infectious or symptoms	21	Thornhill et al. 2022,22 Adler et al. 202226
Fraction of infectious period isolated	All	0.50	Thornhill et al. 2022,22 De Baetselier et al. 202227§
Vaccines available	All	5000	§
Vaccine effectiveness‡	All	0.85	NACI,2 Fine et al. 1988,28 CDC29
Vaccine prioritization sensitivity	Higher risk	0.90	Toronto Public Health3§
Vaccine allocation	City A	0.50 (0–1.0)‡‡	–

Note: CDC = Centers for Disease Control and Prevention, NACI = National Advisory Committee on Immunization, R₀ = basic reproduction number (epidemic potential), SAR = secondary attack rate.

^*All durations are in days; all rates are per day.

^†Fraction of contacts formed exclusively within group;³⁰ 0 implies random mixing between groups and 1 implies no mixing.

^‡Leaky type: partial protection among all vaccinated, not full protection among a fraction vaccinated.

^§Assumed or representative.

^¶Calculated to fit R₀.^1,2

^**Calculated to fit R₀ = 1.5, reflecting prevaccination estimate of monkeypox virus R₀ in Ontario¹⁴ using EpiNow2.¹⁰

^††Calibrated to fit about 95% incidence via sexual versus close nonsexual contacts.

^‡‡Optimized parameter.